What is primary care?

The term primary care refers to the kind of medical care you need first — before you get sick, before you need to see a specialist, before you need to go to a hospital. From preventive medicine to holistic integrative care to home remedies, we leverage the latest medical research, our collective experience and feedback from you to keep you healthy — whether you're already in good health, suffering from a minor cold or experiencing a life-changing illness. Above all, primary care providers offer continuity. In your quest to become and remain as healthy as possible, we are your partners for the long term.

Do you take my insurance?

Yes, we take most commercial plans as well as Original Medicare with or without most Medicare supplement plans and select Medicare Advantage plans. To see if we accept your specific insurance plan, use our insurance finder .

Can I use One Medical if I have insurance that isn’t accepted by your offices?

Yes, we accept self-pay for those without insurance or with insurance where we are out of network.

How can I contact my primary care provider?

If you have a membership, the best (and fastest) way to get in touch with your primary care provider is to message in app/on the website. Alternatively, you can always book an appointment, in-person or remotely, through the office page on Amazon. Appointment booking on the iOS or Android apps is available through the membership only.

Can I get lab work done at One Medical?

Yes! We have drop-in lab services in all offices for labs ordered by One Medical providers and you can also get outside labs done on a drop-in basis. Be sure to confirm the lab hours and you can see average wait times in the app.

Which appointment type should I use?

Looking for your annual physical? Choose “Annual Live Well Visit (Physical)”. Are you having back pain, looking for help managing a chronic condition like high blood pressure, want help identifying the right cancer screenings for you or just want care in person? Choose “In-Office Visit”. Want to discuss your concerns virtually with your chosen provider? Choose “Remote Visit”. Looking for a visit focused on anxious thoughts or feeling low? Choose “Mental Health Visit”. Have another health concern? You can always book an appointment (both in-office or remote) with the provider of your choice. There’s space in the booking process to let us know the purpose of your visit so we can make sure your provider is prepared for your visit so you can get the right care for your concern.

Can you refill my prescriptions? Or help me get a new prescription?

Yes! In some cases, we may need you to have a visit (an In-Office or Remote Visit) prior to refilling a prescription or filling a new one. If you’re already a patient, you can use “Prescription Renewal” in the app.

How do I choose a provider?

You can check out all our providers here . Once you’re a member, you can select a PCP in-app or on the website. Choosing a PCP allows you to get access to more appointment availability.

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Primary Care Doctor's Office in San Francisco, CA Transbay Center

Our Transbay Center office offers exceptional primary care for adults of all ages, including seniors on Medicare. We focus on building real relationships with patients and using technology to simplify every aspect of getting care. And we’re not just here for when you’re sick or injured. We can also help you meet physical and mental health goals, manage chronic illnesses, and live a happier, healthier life. Think of us as your home for healthcare.

Same/next-day appointments available

Book online, no membership needed. Appointments are billed to you or your insurance; copays or deductibles may apply.

Book an Appointment

535 Mission Street

Suite 100

San Francisco , CA 94105

Get Directions

Contact us:

888-663-6331

Office Hours:

Mon, Tue, Fri: 8AM–12PM, 1PM–6PM
Wed–Thu: 8AM–12PM, 1PM–4PM
Sat–Sun: Closed

Lab Hours:

Mon–Fri: 8AM–12PM, 1PM–4PM
Sat–Sun: Closed
Limited Lab collection on Thusdays 8am-12pm and 1pm-4pm

Information

Public Transportation

Muni

F train to Market and 1st or 2nd Street
K-Owl, L-Owl, N-Owl, 2, 5, 5R, 6, 7, 7R, 9, 9R, and 21 all run nearby

San Francisco Metro Transit Home

Bart

All lines to Montgomery

BART Home

Parking

There are parking garages located nearby at 101 2nd Street (ABM Parking Services), 535 Mission (Impark), 100 1st Street (Standard Parking), and 555 Mission (Standard Parking). These parking garages are not affiliated with One Medical. There is limited, metered street parking available.

Additional Information

Our Transbay Center doctor's office is located between 1st Street and 2nd Street, next to Salt House restaurant. There is bike parking in front of the building.

Be aware that we also have an office in the Mission district on Valencia Street. Our Transbay Center office is in SoMa.

Our services

Think of us as your home for healthcare — your go-to for preventive care like physicals and screenings and your first stop when something feels off.

Everyday and preventative care

We’ll help you get healthy and stay that way with state-of-the art screening, disease prevention, and lifestyle advice. Wake up with the flu or a questionable rash? We diagnose and treat a wide spectrum of illnesses, so you get the care you need without having to visit the ER or see specialists.

Learn More Clicking here takes you to the Everyday care page.
Physical exams (we call them Live Well visits)

This is not a one-size-fits-all physical. Before you come in, you’ll answer a few questions in the app about the health issues that matter most to you in order to guide your visit — from mental health to diet and exercise to sexual health.

Learn More Clicking here takes you to the Physical/Annual Exams page.
Women's health

While many women believe they need to see an OB/GYN for women’s health matters, the truth is One Medical’s primary care providers are equipped to handle most women’s health issues, including birth control, sexual health, cancer screenings, menopause, preventive care, aging, gynecological problems, and more.

Learn More Clicking here takes you to the Women’s health page.
Mental health

Your mental health is an important part of the full picture. Whether you're feeling off or experiencing depression, anxiety, insomnia, or something more complex, our suite of mental health services – Mindset by One Medical – is here to help.

Learn More Clicking here takes you to the Mental Health services at One Medical page.

Providers

See all 4 providers

Frequently asked questions

The term primary care refers to the kind of medical care you need first — before you get sick, before you need to see a specialist, before you need to go to a hospital.
From preventive medicine to holistic integrative care to home remedies, we leverage the latest medical research, our collective experience and feedback from you to keep you healthy — whether you're already in good health, suffering from a minor cold or experiencing a life-changing illness.
Above all, primary care providers offer continuity. In your quest to become and remain as healthy as possible, we are your partners for the long term.
If you have a membership, the best (and fastest) way to get in touch with your primary care provider is to message in app/on the website. Alternatively, you can always book an appointment, in-person or remotely, through the office page on Amazon. Appointment booking on the iOS or Android apps is available through the membership only.
Looking for your annual physical? Choose “Annual Live Well Visit (Physical)”.
Are you having back pain, looking for help managing a chronic condition like high blood pressure, want help identifying the right cancer screenings for you or just want care in person? Choose “In-Office Visit”.
Want to discuss your concerns virtually with your chosen provider? Choose “Remote Visit”.
Looking for a visit focused on anxious thoughts or feeling low? Choose “Mental Health Visit”.
Have another health concern? You can always book an appointment (both in-office or remote) with the provider of your choice. There’s space in the booking process to let us know the purpose of your visit so we can make sure your provider is prepared for your visit so you can get the right care for your concern.